利用基因改造的蝗虫从美国中西部一处高度机密的研究机构中逃脱了，它们展开一场舐血的疯狂食人之战。一群专家开始想办法扑灭这些蝗虫，再晚一步，若是蝗虫的声势与数量持续扩大，恐怕无人能幸免。Entomologist Colt left the firm of his ex Vicky's dad Russ and his ruthless partner Gary, in order to regain his scientific independence and ethical virginity. After people are found on several founds with strange bite-marks, which turn out to be the work genetically miss-manipulated locusts, Colt teams up again with Vicky, who works for the public health authorities. After analyzing the facts, they join the heroic, possibly hopeless fight to stop the locust swarm spreading and endangering millions in most of Northern America.
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